solute carrier family 39 member 2 (SLC39A2, Zn+2 transporter ZIP2, Eti-1, 6A1, hZIP2)

Function

• mediates Zn+2 uptake.
• Zn+2 uptake may be mediated by a Zn+2/HCO3- symport
• functions in the presence of albumin
• may also transport other divalent cations
• role in contact inhibition of epithelial cells (putative)
• Zn+2 uptake is inhibited at pH levels < 7.0
• inhibited by Cu+2, Co+2 & Mn+2, but not Fe+2

Structure

belongs to the ZIP transporter (TC 2.A.5) family

Compartment

cell membrane

Expression

• expressed only in prostate & uterine epithelial cells
• expression induced in epithelial cells by contact inhibition

Pathology

• loss of expression may play a role in tumorigenesis

More general terms

• solute carrier family 39 (SLC39, SLC39A)
• transmembrane 8e protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2998
• UniProt: http://www.uniprot.org/uniprot/Q9NP94.html