solute carrier family 39 member 1 (SLC39A1, Zn+2 transporter ZIP1, hZIP1, Zrt- & Irt-like protein 1, IRT1, Zn+2-iron-regulated transporter-like, ZIRTL, CGI-08, CGI-71)

Function

• mediates Zn+2 uptake
• may function as a major endogenous Zn+2 uptake transporter in many cells
• rapid uptake & accumulation of Zn+2 in prostate
• inhibited by Ni+2, but not Fe+2

Structure

belongs to the ZIP transporter (TC 2.A.5) family

Compartment

• cell membrane
• endoplasmic reticulum membrane
• vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines

Expression

• ubiquitous
• expressed in most adult & fetal tissues including epidermis

More general terms

• solute carrier family 39 (SLC39, SLC39A)
• transmembrane 8e protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2717
• OMIM: https://mirror.omim.org/entry/604740
• UniProt: http://www.uniprot.org/uniprot/Q9NY26.html