solute carrier family 34 member 3 (SLC34A3, Na+ dependent phosphate transport protein 2C, Na+/phosphate cotransporter 2C, Na+/Pi cotransporter 2C, NaPi-2c, NPT2C)

Function

• active transport of phosphate into cells via Na+ cotransport in the renal brush border membrane
• probably mediates 20-30% of the apical influx

Kinetic parameters: KM=79 uM for phosphate

2:1 stoichiometry to Na+/Pi is observed at pH 7.4

Structure

belongs to the SLC34A transporter family

Compartment

membrane

Pathology

• defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria

More general terms

• transmembrane 8 protein
• solute carrier family 34 (SLC34, SLC34A)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1426
• OMIM: https://mirror.omim.org/entry/241530
• OMIM: https://mirror.omim.org/entry/609826
• UniProt: http://www.uniprot.org/uniprot/Q8N130.html