solute carrier family 8 member 3 (SLC8A3, Na+/Ca+2 exchanger 3, NCX3)

Function

• rapid transport of Ca+2 during excitation-contraction coupling
• Ca+2 is extruded from the cell during relaxation so as to prevent Ca+2 overloading of intracellular stores (putative)

Structure

• belongs to the Na+/K+/Ca+2 exchanger family, SLC8 subfamily
• contains 2 calx-beta domains

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• isoform 2: brain & skeletal muscle
• isoform 3: excitable cells of brain, retina & skeletal muscle
• isoform 4; skeletal muscle

More general terms

• solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
• transmembrane 11e protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6547
• OMIM: https://mirror.omim.org/entry/607991
• UniProt: http://www.uniprot.org/uniprot/P57103.html