ATP-binding cassette, sub-family A, member 8 (ABCA8, KIAA0822)

Function

• ATP-dependent lipophilic drug transporter

Kinetic parameters:

• KM=30.4 uM for estradiol-beta-glucuronide
• KM=0.1 uM for LTC4
• KM=10.3 uM for taurochlorate
• KM=5.0 uM for PAH
• KM=0.5 uM for estrone sulfate

Structure

• belongs to the ABC transporter family. ABCA subfamily
• contains 2 ABC transporter domains

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• higher expression in heart, skeletal muscle & liver

More general terms

• ATP-binding cassette sub-family A (ABC transporter-A, ABCA)
• transmembrane 14 protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10351
• UniProt: http://www.uniprot.org/uniprot/O94911.html