Na+/H+ exchanger NHE5 (solute carrier family 9 isoform A5, SLC9A5)

Function

• role in pH regulation to eliminate acids generated by active metabolism or adverse environmental conditions
• major proton extruding system
• driven by the inward Na+ chemical gradient
• role in signal transduction (putative)
• phosphorylated (possible)

Structure

• belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Compartment

membrane

Expression

• expressed in brain, testis, spleen, & skeletal muscle

More general terms

• transmembrane 12 protein
• solute carrier family 9 (SLC9, SLC9A)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6553
• OMIM: https://mirror.omim.org/entry/600477
• UniProt: http://www.uniprot.org/uniprot/Q14940.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6553