pulmonary surfactant-associated protein C; SP-C; pulmonary surfactant-associated proteolipid SPL(Val); SP5 (SFTPC, SFTP2)
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Function
- pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces
Structure
contains 1 BRICHOS domain
Compartment
-secreted, extracellular space, surface film
Alternative splicing
named isoforms=2
Pathology
- defects in SFTPC are the cause of pulmonary surfactant metabolism dysfunction type 2 (pulmonary alveolar proteinosis due to SFTPC deficiency)
- genetic variations in SFTPC are a cause of susceptibility to neonatal respiratory distress syndrome
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P11686.html
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/SFTPC
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/sftpc/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6440
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6440
- OMIM: https://mirror.omim.org/entry/178620
- OMIM: https://mirror.omim.org/entry/267450
- OMIM: https://mirror.omim.org/entry/610913
- UniProt: http://www.uniprot.org/uniprot/P11686.html