basic salivary proline-rich protein 4; salivary proline-rich protein Po; parotid o protein; salivary proline-rich protein II-1, [Contains: protein N1; glycosylated protein A; Peptide P-D] (PRB4)

Function

• proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine
• the endoprotease may be of microbial origin
• pyroglutamate formation found on at least Gln-46, Gln-48, Gln-67, Gln-88; Gln-90; Gln-193; Gln-288 Gln-214 & Gln-295, preferentially in diabetic, & head & neck cancer patients

Structure

• N-glycosylated

Compartment

secreted

Polymorphism

• number of repeats is polymorphic & varies among different alleles
• allele S (short), allele M (medium) & allele L (long) contain 6, 7 & 9 tandem repeats respectively

More general terms

• salivary proline-rich protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5545
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5545
• OMIM: https://mirror.omim.org/entry/180990
• UniProt: http://www.uniprot.org/uniprot/P10163.html