collagen 27 alpha-1 (COL27A1, KIAA1870)

Function

• role during the calcification of cartilage & the transition of cartilage to bone

Structure

• belongs to the fibrillar collagen family
• contains 16 collagen-like domains
• contains 1 laminin G-like domain
• contains 1 TSP N-terminal (TSPN) domain

Compartment

• secreted, extracellular space, extracellular matrix
• found on some small banded collagen fibrils & meshworks (putative)

Alternative splicing

named isoforms=3

Expression

• detected at E67 in the primary ossification center
• tightly restricted to the pericellular region of the hypertrophic chondrocytes & lacunae at the very center of the future diaphysis
• at fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction
• weakly detected around cells in the resting & proliferative zone of the cartilagenous plate, but intense detection occurred deep in the hypertrophic zone near the newly formed bone
• detected throughout the extracellular matrix (ECM)
• closely situated around hypertrophic chondrocytes

More general terms

• collagen subunit
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85301
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85301
• OMIM: https://mirror.omim.org/entry/608461
• UniProt: http://www.uniprot.org/uniprot/Q8IZC6.html