corticosteroid-binding globulin; CBG; Serpin A6; transcortin (SERPINA6, CBG)

Function

• major transport protein for glucocorticoids & progestins in plasma of almost all vertebrate species
• 90% of circulating cortisol is bound to plasma proteins, primarily to corticosteroid-binding globulin
• there is also weak binding to albumin

Structure

• N-glycosylated
  • binds 5 oligosaccharide chains
  • glycosylation in position Asn-260 is needed for steroid binding
• belongs to the serpin family

Compartment

secreted

Expression

• expressed in liver, secreted into plasma
• identified in a number of glycocorticoid responsive cells

Pathology

• defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency

More general terms

• alpha globulin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=866
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:866
• OMIM: https://mirror.omim.org/entry/122500
• OMIM: https://mirror.omim.org/entry/611489
• UniProt: http://www.uniprot.org/uniprot/P08185.html