alpha-N-acetylglucosaminidase; N-acetyl-alpha-glucosaminidase; NAG (NAGLU, UFHSD1)

Function

• degradation of heparan sulfate
• hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides

Structure

monomer & homodimer

Compartment

lysosome

Expression

• expressed in liver, ovary, peripheral blood leukocytes, testis, prostrate, spleen, colon, lung, placenta, kidney

Pathology

• defects in NAGLU are the cause of mucopolysaccharidosis 3B

Laboratory

• alpha-N-acetylglucosaminidase in fibroblasts
• alpha-N-acetylglucosaminidase in leukocytes
• alpha-N-acetylglucosaminidase in tissue
• alpha-N-acetylglucosaminidase in serum/plasma
• alpha-N-acetylglucosaminidase in urine

More general terms

• glucosaminidase
• glycoprotein

Additional terms

• Sanfillipo B syndrome; mucopolysaccharidosis 3B

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4669
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4669
• OMIM: https://mirror.omim.org/entry/252920
• OMIM: https://mirror.omim.org/entry/609701
• UniProt: http://www.uniprot.org/uniprot/P54802.html