group IIF secretory phospholipase A2; GIIF sPLA2; sPLA2-IIF; phosphatidylcholine 2-acylhydrolase 2F (PLA2G2F)

Function

• catalyzes Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
• hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference

Cofactor: binds 1 Ca+2 per subunit

Structure

belongs to the phospholipase A2 family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed at high levels in placenta, testis, thymus
• expressed at lower levels in heart, kidney, liver & prostate

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• Ca+2 binding protein
• secreted protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64600
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64600
• UniProt: http://www.uniprot.org/uniprot/Q9BZM2.html