group 2E secretory phospholipase A2; GIIE sPLA2; sPLA2-IIE; phosphatidylcholine 2-acylhydrolase 2E (PLA2G2E)

Function

• catalyzes Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
• preference for arachidonic-containing phospholipids

phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

Cofactor: binds 1 Ca+2 per subunit

Structure

belongs to the phospholipase A2 family

Compartment

secreted

Expression

• expression restricted to brain, heart, lung, & placenta

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• secreted protein
• glycoprotein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30814
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:30814
• UniProt: http://www.uniprot.org/uniprot/Q9NZK7.html