group 12A secretory phospholipase A2; GXII sPLA2; sPLA2-XII; phosphatidylcholine 2-acylhydrolase 12A (PLA2G12A, PLA2G12, FKSG38, UNQ2519/PRO6012)

Function

• catalyzes Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
• no detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine

phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

Cofactor: binds 1 Ca+2 per subunit (putative)

Structure

belongs to the phospholipase A2 family

Compartment

secreted. cytoplasm

Expression

• abundantly expressed in heart, skeletal muscle, kidney, liver & pancreas

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• secreted protein
• glycoprotein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81579
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81579
• OMIM: https://mirror.omim.org/entry/611652
• UniProt: http://www.uniprot.org/uniprot/Q9BZM1.html