group 10 secretory phospholipase A2; group X secretory phospholipase A2; GX sPLA2; sPLA2-X; phosphatidylcholine 2-acylhydrolase 10 (PLA2G10)

Function

• PA2 catalyzes Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
• facilitates releae of arachidonic acid from cell membrane phospholipids
• prefers phosphatidylethanolamine & phosphatidylcholine liposomes to those of phosphatidylserine

phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

Cofactor: binds 1 Ca+2 per subunit

Structure

belongs to the phospholipase A2 family

Compartment

secreted

Expression

• found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, & colon

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• Ca+2 binding protein
• secreted protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8399
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8399
• OMIM: https://mirror.omim.org/entry/603603
• UniProt: http://www.uniprot.org/uniprot/O15496.html