transmembrane protease serine 5; spinesin (TMPRSS5)

Function

• may play a role in hearing

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain
• contains 1 SRCR domain

Compartment

• cell membrane
• single-pass type 2 membrane protein (putative)

Expression

• brain-specific
• predominantly expressed in neurons, in their axons, & at the synapses of motoneurons in the spinal cord

Pathology

• defects in TMPRSS5 may be a cause of deafness

More general terms

• transmembrane serine protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80975
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80975
• OMIM: https://mirror.omim.org/entry/606751
• UniProt: http://www.uniprot.org/uniprot/Q9H3S3.html