liver carboxylesterase; carboxylesterase 1; monocyte/macrophage serine esterase 1; acyl coenzyme A:cholesterol acyltransferase; ACAT; triacylglycerol hydrolase; TGH; Egasyn; brain carboxylesterase hBr1 (CES1, CES2)

Function

• detoxification of xenobiotics
• activation of ester & amide prodrugs
• hydrolyzes aromatic & aliphatic esters
• no catalytic activity toward amides or fatty acyl CoA ester
• binds to beta-glucuronidase

Structure

• homotrimer, homohexamer
• contains sialic acid

Compartment

endoplasmic reticulum lumen

Expression

expressed in liver > heart, lung

Laboratory

• CES1 gene c.428G>A

More general terms

• carboxylase (carboxylic ester hydrolase)
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P23141.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1066
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1066
• OMIM: https://mirror.omim.org/entry/114835