ribonuclease 7; Rnase 7; skin-derived antimicrobial protein 2; SAP-2 (RNASE7)

Function

• potent Rnase activity
• broad-spectrum antimicrobial activity against many pathogenic microorganisms, including:
  • vancomycin-resistant Enterococcus faecium (VRE) (lethal dose of 90% < 30 nM)

Structure

belongs to the pancreatic ribonuclease family

Compartment

secreted

Expression

• expressed in various epithelial tissues including: skin, respiratory tract, genito-urinary tract > GI tract
• expressed in liver, kidney, skeletal muscle & heart

More general terms

• endoribonuclease
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H1E1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84659
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8465