amiloride-sensitive amine oxidase; histaminase; amiloride-binding protein 1; diamine oxidase; DAO; amiloride-binding protein; ABP; kidney amine oxidase (KAO, ABP1, AOC, DAO1)

Function

• catalyzes degradation of compounds including: putrescine, histamine, spermine, & spermidine, substances involved in allergic & immune responses, cell proliferation, tissue differentiation, tumor formation, & possibly apoptosis
• placental DAO is thought to play a role in the regulation of female reproductive function
• topaquinone is generated by copper-dependent autoxidation of a specific Tyr
• inhibited by amiloride (competitive inhibition)

RCH(2)NH(2) + H2O + O2 <--> RCHO + NH3 + H2O2

Cofactor:

• binds 1 copper ion per subunit (putative)
• binds 2 Ca+2 per subunit (putative)
• contains 1 topaquinone per subunit (putative)

Structure

belongs to the copper/topaquinone oxidase family

Compartment

secreted, extracellular space

Alternative splicing

named isoforms=2

Expression

placenta & kidney

Laboratory

• diamine oxidase in serum/plasma

More general terms

• amine oxidoreductase
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P19801.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26
• OMIM: https://mirror.omim.org/entry/104610
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26