elastase-1; pancreatic elastase 1; chymotrypsin-like elastase family member 1 (ELA1, CELA1)

Function

• hydrolysis of proteins, including elastin
• preferential cleavage: Ala-|-Xaa

Cofactor: binds 1 Ca+2 per subunit (putative)

Structure

• belongs to the peptidase S1 family, elastase subfamily
• contains 1 peptidase S1 domain

Compartment

secreted

Expression

skin; not expressed in pancreas

Laboratory

• pancreatic elastase in body fluid
  • pancreatic elastase in serum
    • pancreatic elastase free in serum
  • pancreatic elastase in stool

More general terms

• elastase
• Ca+2 binding protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/130120
• UniProt: http://www.uniprot.org/uniprot/Q9UNI1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1990