cathepsin-F (CTSF, CATSF)

Function

• thiol protease
• role in intracellular degradation & turnover of proteins (putative)
• recombinant enzyme cleaves synthetic substrates with Phe & Leu (better than Val)

Structure

belongs to the peptidase C1 family

Compartment

lysosome

Expression

• expressed in heart, skeletal muscle, brain, testis & ovary > prostate, placenta, liver & colon
• no detectable expression in peripheral leukocytes & thymus

Pathology

• implicated in tumor invasion & metastasis

More general terms

• cathepsin
• aspartic proteinase; carboxyl acid protease
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8722
• OMIM: https://mirror.omim.org/entry/603539
• UniProt: http://www.uniprot.org/uniprot/Q9UBX1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8722