carboxypeptidase A6 (CPA6, CPAH)

Function

• release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

belongs to the peptidase M14 family

Compartment

secreted (putative)

Alternative splicing

named isoforms=3

Pathology

• chromosomal translocation t(6;8)(q26;q13) disrupting CPA6 was found in a patient with Duane retraction syndrome

More general terms

• carboxypeptidase-A
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57094
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5709
• OMIM: https://mirror.omim.org/entry/126800
• UniProt: http://www.uniprot.org/uniprot/Q8N4T0.html