inter alpha antitrypsin heavy chain-4 (ITI heavy chain H4, inter-alpha-inhibitor heavy chain 4, inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP, plasma kallikrein sensitive glycoprotein 120, PK-120, GP120, ITIH4, IHRP, ITIHL1, PK120, PRO1851)

Function

• involved in acute phase reactions
• levels increase significantly in sera of patients after surgical trauma
• cleaved by plasma kallikrein to yield 100 kD & 35 kD fragments
  • 100 kD fragment is further converted to 70 kD fragment

Structure

• belongs to the ITIH family
• contains 1 VWFA domain
• appears to be both N- & O-glycosylated
• O-linked polysaccharides on Ser-696, Thr-701 & Ser-702 are probably the mucin type linked to galNAc

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

liver specific

Pathology

• levels increase significantly in the sera of patients after different surgical trauma

More general terms

• inter alpha antitrypsin heavy chain
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/600564
• UniProt: http://www.uniprot.org/uniprot/Q14624.html