inter alpha antitrypsin heavy chain-1 (inter-alpha-trypsin inhibitor heavy chain H1 precursor, ITI heavy chain H1, inter-alpha-trypsin inhibitor complex component 3, serum-derived hyaluronan-associated protein, SHAP, ITIH1, IGHEP1)

Function

• component of I-alpha-I
• carrier of hyaluronan in serum or binding protein between hyaluronate & other matrix protein(s)
• contains a potential peptide potentially stimulating phagocytotic cells

Structure

• belongs to the ITIH family
• contains 1 VWFA domain
• S-linked glycan is composed of two units of either Glc or Gal
• Mass Spectroscopy: mass=76258; method=MALDI; Range=28-672

Compartment

secreted

Polymorphism

3 common alleles

More general terms

• inter alpha antitrypsin heavy chain
• glycoprotein

Component of

• inter alpha trypsin inhibitor (inter-alpha-inhibitor, I-alpha-I)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3697
• OMIM: https://mirror.omim.org/entry/147270
• UniProt: http://www.uniprot.org/uniprot/P19827.html