protein FAM65B (FAM65B C6orf32 DIFF48 KIAA0386 PL48)

Function

• isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement & filopodia formation
• Asn-41 may be N-glycosylated; however as this position is probably not extracellular, the in vivo relevance is not proven

Structure

belongs to the FAM65 family

Compartment

• isoform 1: mitochondrion.
• isoform 2: cytoplasm, cytoskeleton
• detected in cellular filopodia

Alternative splicing

named isoforms=2

Expression

• isoform 1 is present in brain
• isoform2 is expressed during differentiation of fetal primary myoblasts
• isoform 2 also shows marked expression during cytotrophoblast differentiation

Notes

• cells lacking isoform 2 exhibit a severe reduction of myotube formation
• in contrast, isoform 2 overexpression induces formation of filopodia

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y4F9.html