Rap1 GTPase-activating protein 2 (Rap1GAP2, GTPase-activating Rap/Ran-GAP domain-like protein 4, GARNL4, KIAA1039, RAP1GA2)

Function

• GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state
• in vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity

Structure

contains 1 Rap-GAP domain

Compartment

cytoplasm. cytoplasm, perinuclear region

Alternative splicing

named isoforms=3

Expression

• isoform 1 & isoform 2 are expressed in platelets with isoform 2 being the predominant form
• expressed in lymphocytes, heart, testis & pancreas

More general terms

• rap GTPase-activating protein (rap-GAP)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q684P5.html