FAD synthetase (FMN adenylyltransferase, FAD pyrophosphorylase, flavin adenine dinucleotide synthetase, [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthetase region], FLAD1)

Function

• catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme
• cofactor biosynthesis, FAD biosynthesis, FAD from FMN: step 1/1

ATP + FMN <--> diphosphate + FAD

Cofactor: Mg+2

Kinetic parameters:

• KM=1.5 uM for FMN (isoform 1)
• KM=0.36 uM for FMN (isoform 3)
• Vmax=6.1 nmol/min/mg enzyme (isoform 1)
• Vmax=3.9 nmol/min/mg enzyme (isoform 3)

Structure

• molybdenum cofactor biosynthesis protein-like region may not be functional family reductase family, FAD1 subfamily

Alternative splicing

named isoforms=5

More general terms

• phosphoprotein
• nucleotidyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NFF5.html