anti-MysB antibody

Etiology

• positive in 80% of patients with Lambert-Eaton mysasthenic syndrome due to lung cancer (small cell carcinoma)
• generally negative in patients with Lambert-Eaton syndrome secondary to non-lung cancer
• 36% of patients have no evidence of cancer

Pathology

Neuronal antigen:

• beta-2 subunit of presynaptic voltage-gated Ca+2 channel (Lambert-Eaton myasthenic syndrome antigen B)

More general terms

• paraneoplastic autoantibody

Additional terms

• Lambert-Eaton myasthenic syndrome (LEMS)
• voltage-dependent L-type Ca+2 channel beta-2; CAB2; Ca+2 channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB (CACNB2, CACNLB2, MYSB)