salvador homolog 1 protein (45 kD WW domain protein, hWW45, SAV1, WW45)

Function

• scaffold protein
• phosphorylated by STK3 & STK4
• phosphorylation is not required for SAV1 stability, but may increase the number of protein binding sites

Structure

• homodimer, stabilized through interaction with STK3 or STK4
• contains 1 SARAH domain
• contains 2 WW domains

Expression

• ubiquitously expressed in adult tissues
• highest expression in the pancreas, aorta & interventricular septum
• lowest expression in skeletal muscle
• expression higher in fetal than in adult heart

More general terms

• scaffold protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607203
• UniProt: http://www.uniprot.org/uniprot/Q9H4B6.html