AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A, B-cell regulator of IgH transcription, Bright, E2F-binding protein 1, ARID3A, DRIL1, DRX, E2FBP1)

Function

• binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription
• binds minor groove of a restricted ATC sequence sufficient for nuclear matrix association
  • sequence motif is present in matrix-associating regions proximal to the promoter & flanking E mu
  • activates E mu-driven transcription by binding these sites

Structure

• contains 1 ARID domain
• contains 1 NAP domain (nucleosome assembly protein domain)

Compartment

nucleus

Expression

• widely expressed
• highest expression in skeletal muscle, thalamus, colon

More general terms

• AT-rich interactive domain-containing protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603265
• UniProt: http://www.uniprot.org/uniprot/Q99856.html