renin receptor (renin/prorenin receptor, {ATPase, H+- transporting, lysosomal accessory protein 2}, vacuolar ATP synthase membrane sector-associated protein M8-9, V-ATPase M8.9 subunit, ATP6M8-9, N14F, ER-localized type 1 transmembrane adaptor, embryonic liver differentiation factor 10, ATP6AP2, ATP6IP2, CAPER, ELDF10, HT028, MSTP009, PSEC0072)

Function

• renin & prorenin cellular receptor
• renin-dependent cellular responses
  • activates ERK1 & ERK2
• increases catalytic efficiency of renin in angiotensinogen conversion to angiotensin 1
• renin-angiotensin system
• interacts with renin & vacuolar proton-ATPase
• phosphorylated

Compartment

membrane

Expression

• expressed in brain, heart, placenta, liver, kidney, pancreas > lung, skeletal muscles
• in kidney cortex restricted to the mesangium of glomeruli
• in coronary arteries & renal artery, expressed in subendothelium, associated with smooth muscles

Pathology

• defects in ATP6AP2 are a cause of X-linked mental retardation with epilepsy
• a silent mutation, exon skipping occurs

More general terms

• cell surface receptor
• phosphoprotein

Additional terms

• prorenin
• renin; angiotensinogenase (REN)
• X-linked mental retardation with epilepsy (MRXE)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1015
• OMIM: https://mirror.omim.org/entry/300423
• OMIM: https://mirror.omim.org/entry/300556
• UniProt: http://www.uniprot.org/uniprot/O75787.html