heat shock transcription factor-2; heat shock factor protein-2 (HSTF2, HSF2)

Function

• DNA-binding protein that specifically binds heat shock promoter elements (HSE) & activates transcription
• in higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked
• DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer

Structure

belongs to the HSF family

Compartment

• cytoplasm, nucleus
• cytoplasmic during normal growth & moves to the nucleus upon activation

More general terms

• heat shock factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q03933.html
• OMIM: https://mirror.omim.org/entry/140581
• OMIM: https://mirror.omim.org/entry/140580
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3298