nicotinamide mononucleotide adenylyltransferase 3; NMN adenylyltransferase 3; nicotinate-nucleotide adenylyltransferase 3; NaMN adenylyltransferase 3; pyridine nucleotide adenylyltransferase 3; PNAT-3 (NMNAT3)

Function

• NAD+ biosynthesis
• phosphorylated

ATP + nicotinamide ribonucleotide  <-->  diphosphate + NAD+

Cofactor: divalent metal cations

Inhibition:

• strongly inhibited by galotannin
• inhibited by Nap4AD

Structure

• homohexamer
• belongs to the eukaryotic NMN adenylyltransferase family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in lung & spleen
• lower levels in placenta & kidney

More general terms

• nicotinamide mononucleotide adenylyltransferase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=349565
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:349565
• OMIM: https://mirror.omim.org/entry/608702
• UniProt: http://www.uniprot.org/uniprot/Q96T66.html