pyrophosphomevalonate decarboxylase (diphosphomevalonate decarboxylase, mevalonate pyrophosphate decarboxylase, mevalonate [diphospho]decarboxylase, MVD MPD)

Function

• performs 1st committed step in the biosynthesis of isoprenes
• cholesterol biosynthesis

ATP + (R)-5-diphosphomevalonate
            <-->
ADP + phosphate + isopentenyl diphosphate + CO2

Structure

• homodimer
• belongs to the diphosphomevalonate decarboxylase family

Expression

• expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney & placenta

Pathology

• mutations associated with linear porokeratosis

More general terms

• carboxy-lyase or decarboxylase
• phosphoprotein

Additional terms

• cholesterol biosynthesis

Database

• OMIM: https://mirror.omim.org/entry/603236
• UniProt: http://www.uniprot.org/uniprot/P53602.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4597