kinesin family member C1 (Kifc1, kinesin-like protein 2, kinesin-related protein HSET, KIFC1, HSET, KNSL2)

Function

• minus end-directed microtubule-dependent motor required for bipolar spindle formation
• may contribute to movement of early endocytic vesicles
• binds NUBP1 & NUBP2 (putative)

Structure

• belongs to the kinesin-like protein family, NCD subfamily
• contains 1 kinesin-motor domain

Compartment

• nucleus (putative)
• centrosome, spindle
• early endosome
• associated with nucleus during interphase, centrosomes in early & spindle in later mitosis (putative)

Pathology

• HeLa cells lacking KIFC1 show multipolar mitotic spindles & a defect in chromosome congression & chromosome alignment during mitosis

More general terms

• kinesin family protein
• nuclear protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603763
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3833
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3833
• UniProt: http://www.uniprot.org/uniprot/Q9BW19.html