aldehyde dehydrogenase 1 family, member A2; retinal dehydrogenase 2; retinaldehyde-specific dehydrogenase type 2 (ALDH1A2, RALDH2)

Function

• recognizes as substrates free retinaldehyde & retinaldehyde bound to cellular retinol-binding protein
• does metabolize octanal & decanal but does not metabolize citral, benzaldehyde, acetaldehyde & propanal efficiently (putative)
• retinoic acid biosynthesis

retinaldehyde + NAD+ + H2O <--> retinoic acid + NADH + H+

Structure

• homotetramer (putative)
• belongs to the aldehyde dehydrogenase family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• aldehyde dehydrogenase
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8854
• OMIM: https://mirror.omim.org/entry/603687
• UniProt: http://www.uniprot.org/uniprot/O94788.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8854