long chain fatty-acid CoA ligase-1 (long chain fatty-acid CoA ligase-2, long-chain acyl CoA synthetase-1/2, LACS-1, LACS-2, palmitoyl-CoA ligase 1/2, acyl-CoA synthetase 1, ACSL1)

Function

• activation of long-chain fatty acids for both synthesis of cellular lipids, & degradation via beta-oxidation
• preferentially uses palmitoleate, oleate & linoleate

ATP + a long-chain carboxylic acid + CoA
              <-->
AMP + diphosphate + an acyl-CoA

Cofactor: Mg+2

Structure

• belongs to ATP-dependent AMP-binding enzyme family

Compartment

• mitochondrial outer membrane
• peroxisome membrane
• microsome membrane
• endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• expressed in liver, heart, skeletal muscle, kidney & erythroid precursors > brain, lung, placenta & pancreas
• expressed during the early stages of erythroid development, expression is very low in reticulocytes & young erythrocytes

More general terms

• fatty-acid CoA ligase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P33121.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2180
• OMIM: https://mirror.omim.org/entry/152425