peptidase-D (proline dipeptidase, prolidase, Xaa-Pro dipeptidase, X-Pro dipeptidase, imidodipeptidase, PEPD, PRD)

Function

• splits dipeptides with a Pro or hydroxyprolyl residue in the C-terminal position
• role in collagen metabolism because the high level of iminoacids in collagen
• hydrolysis of Xaa-|-Pro dipeptides
• also active on aminoacyl-hydroxyproline analogs
• no action on Pro-|-Pro

Cofactor: binds 2 Mn+2 per subunit (putative)

Structure

• homodimer, mass=54251
• belongs to the peptidase M24B family, eukaryotic-type prolidase subfamily

Expression

• upregulated 8-fold after environmental enrichment

Pathology

• defects in PEPD are a cause of prolidase deficiency
• tight linkage between the polymorphisms of prolidase & myotonic dystrophy trait

More general terms

• dipeptidase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P12955.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5184
• OMIM: https://mirror.omim.org/entry/170100
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5184