copper chaperone for superoxide dismutase; superoxide dismutase copper chaperone (CCS)

Function

• delivers copper to copper Zn+2 superoxide dismutase (SOD1)
• homodimer, & heterodimer with SOD1

Cofactor:

• binds 2 copper ions per subunit
• binds 1 Zn+2 per subunit

Structure

• in the C-terminal section; belongs to the Cu-Zn superoxide dismutase family
• contains 1 HMA domain

Compartment

cytoplasm

Expression

ubiquitous

More general terms

• metalloprotein
• phosphoprotein

Additional terms

• Cu/Zn superoxide dismutase (SOD-1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9973
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9973
• OMIM: https://mirror.omim.org/entry/603864
• UniProt: http://www.uniprot.org/uniprot/O14618.html