epidermis-type lipoxygenase 3; e-LOX-3 (ALOXE3)

Function

• introduces molecular oxygen into polyunsaturated fatty acids
• exact substrate is unknown
• lipid metabolism; leukotriene D4 biosynthesis

Cofactor: binds 1 iron ion per subunit (putative)

Structure

• belongs to the lipoxygenase family
• contains 1 lipoxygenase domain
• contains 1 PLAT domain

Expression

predominantly expressed in skin

Pathology

defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma 1

More general terms

• dioxygenase
• metalloprotein

Additional terms

• nonbullous congenital ichthyosiform erythroderma 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59344
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:59344
• OMIM: https://mirror.omim.org/entry/242100
• OMIM: https://mirror.omim.org/entry/607206
• UniProt: http://www.uniprot.org/uniprot/Q9BYJ1.html