inorganic pyrophosphatase; pyrophosphate phospho-hydrolase; PPase (PPA1, IOPPP, PP)

Function

diphosphate + H2O = 2 phosphate

Cofactor:

• binds 4 Mg+2 per subunit
• other metal ions can support activity, but at a lower rate
• two Mg+2 are required for the activation of the enzyme & are present before substrate binds
• two additional Mg+2 form complexes with substrate & product (putative)

Structure

• homodimer (putative)
• belongs to the PPase family

Compartment

cytoplasm (putative)

Expression

expressed ubiquitously

More general terms

• pyrophosphatase (diphosphohydrolase)
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5464
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5464
• OMIM: https://mirror.omim.org/entry/179030
• UniProt: http://www.uniprot.org/uniprot/Q15181.html