3-OH anthranilate oxygenase (3-OH anthranilate 3,4-dioxygenase, HAAO)

Function

• catalyzes synthesis of excitotoxin quinolinic acid from 3-hydroxyanthranilic acid
• direct product of the reaction spontaneously rearrange to quinolinic acid

3-hydroxyanthranilate + O2
         <-->
2-amino-3-carboxymuconate semialdehyde

Cofactor: Fe+2 ion

Structure

• monomer
• belongs to the 3-HAO family

Compartment

cytoplasm

More general terms

• oxygenase
• metalloprotein

Additional terms

• kynurenine pathway

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2349
• OMIM: https://mirror.omim.org/entry/604521
• UniProt: http://www.uniprot.org/uniprot/P46952.html