inositol-1,4,5-trisphosphate 5-phosphatase type 1; 5PTase (INPP5A)

Function

• major isoenzyme hydrolyzing the Ca+2-mobilizing second messenger ins(1,4,5)P3; this is a signal-terminating reaction

D-myo-inositol-1,4,5-trisphosphate + H2O = myo-inositol-1,4-bisphosphate + phosphate

1D-myo-inositol-1,3,4,5-tetrakisphosphate +H2O = 1D-myo-inositol-1,3,4-trisphosphate + phosphate

Structure

• belongs to the inositol-1,4,5-trisphosphate-5-phosphatase type 1 family

Compartment

membrane; lipid-anchor

Expression

• expressed in brain
• high expression in Purkinje cells

More general terms

• phosphomonoesterase
• prenyl protein

Additional terms

• inositol-1,4,5-triphosphate (IP3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3632
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3632
• OMIM: https://mirror.omim.org/entry/600106
• UniProt: http://www.uniprot.org/uniprot/Q14642.html