guanylyl cyclase activating protein 3; GCAP 3; guanylate cyclase activator 1C (GUCA1C, GCAP3)

Function

• stimulates guanylyl cyclases (GC1 & GC2) when free Ca+2 is low
• inhibits guanylyl cyclases when free Ca+2 is high
• this Ca+2-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure

Structure

contains 4 EF-hand domains

Alternative splicing

named isoforms=2

Expression

retina

Notes

• binds 3 Ca+2 (putative)

More general terms

• Ca+2 binding protein
• myristoylated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9626
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9626
• OMIM: https://mirror.omim.org/entry/605128
• UniProt: http://www.uniprot.org/uniprot/O95843.html