Poly(A) RNA polymerase, mitochondrial (PAP, mtPAP, polynucleotide adenylyltransferase, PAP-associated domain- containing protein 1, PAPD1)

Function

• polymerase that creates the 3' poly(A) tail of mitochondrial transcripts
• might be responsible for creation of some UAA stop codons which are not encoded in mtDNA

ATP + RNA(n) <--> diphosphate + RNA(n+1)

Structure

belongs to the DNA polymerase type-B-like family

Compartment

mitochondria

Alternative splicing

named isoforms=2

Expression

• ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, & skeletal muscle

More general terms

• mitochondrial protein
• nucleotidyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NVV4.html