2,4-dienoyl-CoA reductase, mitochondrial (2,4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase [NADPH], DECR1, DECR)

Function

• auxiliary enzyme of beta-oxidation
• participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- & odd-numbered positions
• catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA

Trans-2,3-didehydroacyl-CoA + NADP+   <-->
           trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH

Structure

• homotetramer
• belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily Commpartment: mitochondrion

Expression

• expressed in heart, liver, pancreas > kidney >> skeletal muscle, lung

More general terms

• mitochondrial protein
• oxidoreductase

Database

• OMIM: https://mirror.omim.org/entry/222745
• UniProt: http://www.uniprot.org/uniprot/Q16698.html