acyl-coenzyme A synthetase ACSM5, mitochondrial (ACSM5, MACS3)

Function

H

• has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro)
• acts on acids from C(4) to C(11) & on the corresponding 3-hydroxy- & 2,3- or 3,4- unsaturated acids (in vitro)

ATP + carboxlate + CoA <--> AMP + diphosphate + acyl-CoA

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

mitochondrial matrix (putative)

Alternative splicing

named isoforms=2

Expression

detected in kidney & liver

More general terms

• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6NUN0.html