acyl-coenzyme A synthetase ACSM2B, mitochondrial (acyl-CoA synthetase medium-chain family member 2B, middle-chain acyl-CoA synthetase 2B, butyrate--CoA ligase 2B, butyryl coenzyme A synthetase 2B, xenobiotic/medium-chain fatty acid-CoA ligase HXM-A, ACSM2B, ACSM2, HYST1046)

Function

• medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro)
• acts on acids from C(4) to C(11) & on the corresponding 3-hydroxy- & 2,3- or 3,4- unsaturated acids (in vitro)
• activated by monovalent cations, such as K+, rubidium or NH4+

ATP + carboxylate + CoA <--> AMP + diphosphate + acyl-CoA

Cofactor: Mg+2 or Mn+2

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

mitochondrial matrix

Expression

detected in liver

More general terms

• mitochondrial protein
• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase

Database

• UniProt: http://www.uniprot.org/uniprot/Q68CK6.html