acyl-coenzyme A synthetase ACSM2A, mitochondrial (scyl-CoA synthetase medium-chain family member 2A, middle-chain acyl-CoA synthetase 2A, butyrate-CoA ligase 2A, butyryl coenzyme A synthetase 2A, ACSM2A, ACSM2, MACS2)

Function

• medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro)
• acts on acids from C(4) to C(11) & on the corresponding 3-hydroxy- & 2,3- or 3,4- unsaturated acids (in vitro)

ATP + an acid + CoA <--> AMP + diphosphate + acyl-CoA

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the ATP-dependent AMP-binding enzymefamily

Compartment

mitochondrial matrix (putative)

More general terms

• mitochondrial protein
• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase

Database

• UniProt: http://www.uniprot.org/uniprot/Q08AH3.html