protoheme IX farnesyltransferase, mitochondrial; heme O synthase (COX10)

Function

• converts protoheme IX & farnesyl diphosphate to heme O

Structure

belongs to the ubiA prenyltransferase family

Compartment

• mitochondrial membrane; multi-pass membrane protein

Pathology

• defects in COX10 are a cause of
  • cytochrome c oxidase deficiency
  • Leigh syndrome

More general terms

• transmembrane 7 protein
• farnesyltransferase
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1352
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1352
• OMIM: https://mirror.omim.org/entry/220110
• OMIM: https://mirror.omim.org/entry/256000
• OMIM: https://mirror.omim.org/entry/602125
• UniProt: http://www.uniprot.org/uniprot/Q12887.html